Try out PMC Labs and tell us what you think. Learn More. E2 induces breast cancer proliferation both in vitro and in vivo , at least in part, by stimulating progression through the G 1 phase of the cell cycle 4 and regulating the transcription of genes that control growth and cell survival 4 , 5. ER proteins act in the nucleus as ligand-activated transcription factors that either bind as dimers to estrogen response elements EREs in the promoters of target genes, or associate with other transcription factors bound to the DNA 6. In addition to its role in the nucleus, ER interacts with and activates cytoplasmic signaling molecules including c-Src, Shc, and phosphatidylinositol 3-kinase 7. Both the nuclear and cytoplasmic actions of ER may play a role in E2-dependent breast cancer. ER transcription can be modulated by selective ER modulators, which have tissue-specific agonist or antagonist functions.
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This book is a volume in the Penn Press Anniversary Collection. To mark its th anniversary in , the University of Pennsylvania Press rereleased more than 1, titles from Penn Press's distinguished backlist from that had fallen out of print. Spanning an entire century, the Anniversary Collection offers peer-reviewed scholarship in a wide range of subject areas. Dallas emerges from this book as one of those truly enviable public figures—a man of charm and wisdom who used his creative energies with untiring vigor for the common good. His life story as told in this highly readable book is of national significance and should be of especial interest to Pennsylvanians. The Song in the Story is the first full-length examination of lyric insertions in medieval French literature. Boulton's discussion of the function of the literary device is firmly placed in the context of contemporary rhetorical theory and the literary trends of the thirteenth and fourteenth centuries.
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Both Refinery29 and The Leftovers creator Damon Lindelof want a very specific addition to the television industry in order to solve the problem of female objectification. In addition, part of this appeal seems to involve a call for more depictions of gay sex on television, which would evidently enhance the quality of entertainment offered to the American public. In addition, the author of this article tried to make this alleged problem into something that should bother both feminists and LBGTQ activists. She praised the show The Leftovers as a fine example of equality in nudity. Cretaz said this is a trend in American culture, especially with the release of a new photo project that focused on photographs of nude males. For some reason, the only way to solve this problem, which seems like it should be a point of feminist outrage, is to show more male nudity. One would think that the common sense way of fixing this situation would be to restore human dignity to actresses on these shows and edit out female nudity. However, of course, the only way to improve the oppressive entertainment industry is to put up more displays of male nudity to balance out the objectification.
Close share via email share via facebook share via twitter. Throughout his career Degas returned to the same figures and motifs again and again, constantly modifying and refining them. One of these was nude women engaged in daily activities like bathing, drying themselves, or brushing their hair. His figures are often depicted from an unusual vantage point and framed asymmetrically. Though they appear unposed, Degas collaborated closely with his models in the studio. Eventually, through continual repetition of a motif or position, he arrived at the point where he could render it from memory and experiment with the form in different configurations of space.
